[卵形成・卵成熟]

  • Yoshitome, S., Furuno, N., Prigent, C. and Hashimoto, E. (2012) The subcellular localization of cyclin B2 is required for bipolar spindle formation during Xenopus oocyte maturation. Biochemical and Biophysical Research communication, 422 770-775
  • Furuno, N., Nishizawa, M., Okazaki, K., Tanaka, H., Iwashita, J., Nakajo N., Ogawa, Y. and Sagata, N. (1994) Suppression of DNA replication via Mos function during meiotic division in Xenopus oocytes. EMBO J. 13, 2399-2410
  • Yoshitome S., Furuno N*., Hashimoto, E. and Sagata N. (2003) The C-terminal seven amino acids in the CRS region of cyclin B2 are required for normal bipolar spindle formation in Xenopus oocytes and embryos. Molecular Cancer Research 1, 589-597 (* Corresponding author)(表紙に図画採用された)
  • Furuno, N., Kawasaki, A. and Sagata, N. (2003) Expression of cell-cycle regulators during Xenopus oogenesis. Gene Expression Patterns 3, 165-168
  • Furuno, N., Ogawa, Y., Iwashita, J., Nakajo, N. and Sagata N. (1997) Meiotic cell cycle in Xenopus oocytes is independent of cdk2 kinase. EMBO J. 16, 3860-3865

[初期発生]

  • Takebayashi-Suzuki, K., Konishi, H., Miyamoto, T., Nagata, T., Uchida, M. and Suzuki, A. “Coordinated regulation of the dorsal-ventral and anterior-posterior patterning of Xenopusembryos by the BTB/POZ zinc finger protein Zbtb14” Development, Growth and Differentiation 60, 158-173 (2018).
  • Suzuki, A., Yoshida, H., van Heeringen, S.J., Takebayashi-Suzuki, K., Veenstra, G.J.C. and Taira, M. “Genomic organization and modulation of gene expression of the TGF-beta and FGF pathways in the allotetraploid frog Xenopus laevis.” Developmental Biology 426, 336–359 (2017).
  • Suzuki, A., Uno, Y., Takahashi, S., Grimwood, J., Schmutz, J., Mawaribuchi, S., Yoshida, H., Takebayashi-Suzuki, K., Ito, M., Matsuda, Y., Rokhsar, D., and Taira, M. “Genome organization of the vg1 and nodal3 gene clusters in the allotetraploid frog Xenopus laevis.” Developmental Biology 426, 336–359 (2017).
  • Haramoto, Y., Saijyo, T., Tanaka, T., Furuno, N., Suzuki, A., Ito, Y., Kondo, M., Taira, M., and Takahashi, S. “Identification and comparative analyses of Siamois cluster genes in the Xenopus laevis and tropicalis.” Developmental Biology 426, 374–383 (2017).
  • Session, A.M., Uno, Y., Kwon, T., Chapman, J., Toyoda, A., Takahashi, S., Fukui, A., Hikosaka, A., Suzuki, A., Kondo, M. et al. “Genome evolution in the allotetraploid frog Xenopus laevis.” Nature 538, 336–343 (2016).
  • Yoshida, H., Okada M., Takebayashi-Suzuki, K., Ueno, N., and Suzuki, A. “Involvement of JunB proto-oncogene in tail formation during early Xenopus embryogenesis.” Zoological Science 33, 282-289 (2016).
  • Takebayashi-Suzuki, K., Kitayama, A., Terasaka-Iioka, C., Ueno, N. and Suzuki, A. “The forkhead transcription factor FoxB1 regulates the dorsal-ventral and anterior-posterior patterning of the ectoderm during early Xenopus embryogenesis.“ Developmental Biology 360, 11-29 (2011).
  • Takebayashi-Suzuki, K., Arita, N., Murasaki, E. and Suzuki, A. “The Xenopus POU class V transcription factor XOct-25 inhibits ectodermal competence to respond to bone morphogenetic protein-mediated embryonic induction.” Mechanisms of Development 124, 840-855 (2007).
  • Takebayashi-Suzuki, K., Funami, J., Tokumori, D., Saito, A., Watabe, T., Miyazono, K., Kanda, A. and Suzuki, A. “Interplay between the tumor suppressor p53 and TGF-beta signaling shapes embryonic body axes in Xenopus.” Development 130, 3929-3939 (2003).
  • Suzuki, A. and Hemmati-Brivanlou, A. “Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis.” Molecular Cell 5, 217-229 (2000).

[生殖器発生・分化・機能]

  • Matsushima N., Ihara S., Takase M., Horiguchi T. Assessment of radiocesium contamination in frogs 18 months after the Fukushima Daiichi nuclear disaster. Scientific Reports 5 : 9712 | DOI: 10.1038/srep09712, 1-6, 2015.
  • Takase, M., Shinto, H., Takao, Y. and Iguchi, T. Accumulation and pharmacokinetics of estrogenic chemicals in the pre- and post-hatch embryos of the frog Rana rugosa. In Vivo 26, 913-920, 2012.
  • Oka, T., Mitsui-Watanabe, N., Tatarazako, N., Onishi, Y., Katsu, Y., Miyagawa, S., Ogino, Y., Yatsu, R., Kohno, S., Takase, M., Kawashima, Y., Ohta, Y., Aoki, Y., Guillette, L.T. Jr. and Iguchi, T. Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors. J. Appl. Toxicol. doi: 10.1002/jat.2825, 2012.
  • Katsu, Y., Taniguchi, E., Urushitani, H., Miyagawa, S., Takase, M., Kubokawa, K., Tooi, O., Oka, T., Santo, N., Myburgh, J., Matsuno, A., Iguchi, T. Molecular cloning and characterization of ligand- and species-specificity of amphibian estrogen receptors. Gen. Comp. Endocrinol. 168, 220-230, 2010.
  • Oka, T., Miyahara, M., Yamamoto, J., Mitsui, N., Fujii, T., Tooi, O., Kashiwagi, K., Takase, M., Kashiwagi, A., Iguchi, T. Application of metamorphosis assay to a native Japanese amphibian species, Rana rugosa, for assessing effects of thyroid system affecting chemicals. Ecotoxicol. Environ. Saf. 72, 1400-1405, 2009.
  • Oka, T., Tooi, O., Mitsui, N., Miyahara, M., Ohnishi, Y., Takase, M., Kashiwagi, A., Shinkai, T., Santo, N., Iguchi, T. Effect of atrazine on metamorphosis and sexual differentiation in Xenopus laevis. Aquat. Toxicol. 87, 215-226, 2008.
  • Takase, M., Iguchi, T. Molecular cloning of two isoforms of Xenopus (Silurana) tropicalis estrogen receptor mRNA and their expression during development. Biochim. Biophys. Acta 1769, 172-181, 2007.
  • Takase, M., Mitsui, N., Oka, T., Tooi, O., Santo, N., Pickford, D.B., Iguchi, T. Development of biomarkers of endocrine disrupting activity in emerging amphibian model, Silurana (Xenopus) tropicalis. Environ. Sci. 14, 285-296, 2007.
  • Kato, T., Matsui, K., Takase, M., Kobayashi, M. and Nakamura, M. Expression of P450 aromatase protein in developing and in sex- reversed gonads of the XX/XY type of the frog Rana rugosa. Gen. Comp. Endocrinol. 173, 227-236, 2004.
  • Aoyama, S., Shibata, K., Tokunaga, S., Takase, M., Matsui, K. and Nakamura, M. Expression of Dmrt1 protein in developing and in sex-reversed gonads of amphibians. Cytogenet. Genome Res. 101, 295-301, 2003.
  • Asahi, H., Takase, M., Yuge, M., Matsui, K., Mori, M., Fujita, T. and Nakamura, M. Expression of FTZ-F1alpha in transgenic Xenopus embryo and oocytes. Dev. Growth Differ. 44, 509-516, 2002.
  • Shibata, K, Takase, M. and Nakamura, M. The Dmrt1 expression in sex-reversed gonads of amphibians. Gen. Comp. Endocrinol. 127, 232-241, 2002.
  • Sugita, J., Takase, M. and Nakamur, M. Expression of Dax-1 during gonadal development of the frog. Gene 280, 67-74, 2001.
  • Takase, M., Nakajima, T. and Nakamura, M. Expression of FTZ- F1alpha in frog testicular cells. J. Exp. Zool. 290, 182-189, 2001.
  • Kawano, K-I, Furusawa, S., Matsuda, H., Takase, M. and Nakamura, M. Expression of steroidogenic factor-1 in frog embryo and developing gonad. Gen. Comp. Endocrinol. 123, 13-22, 2001.
  • Takase, M., Nakajima, T. and Nakamura, M. FTZ-F1α is expressed in the developing gonad of frogs. Biochim. Biophys. Acta 1494, 195-200, 2000.
  • Nakajima, T., Takase, M., Miura, I. and Nakamura,M. Two isoforms of FTZ-F1 messenger RNA: molecular cloning and their expression in the frog testis. Gene 248, 203-212, 2000.
  • Takase, M., Noguchi, S., Nakamura, M. Two Sox9 messenger RNA isoforms: isolation of cDNAs and their expression during gonadal development in the frog Rana rugosa. FEBS Lett. 466, 249-254, 2000.
  • Kawano, K-I., Miura, I., Morohashi, K., Takase, M. and Nakamura, M. Molecular cloning and expression of the SF-1/Ad4BP gene in the frog, Rana rugosa. Gene 222, 169-176, 1998.
  • Takase, M. Differences in genetic backgrounds affecting gonadal differentiation between two local populations of the Japanese wrinkled frog (Rana rugosa). Anat. Embryol. 198, 141-148, 1998.
  • 三浦郁夫、髙瀬 稔、中村正久 蛋白質 核酸 酵素「生殖細胞の発生と性分化」・両生類における性決定,p.462~469,1998年.
  • Takase, M. and Tsutsui, K. Inhibitory role of prolactin in the downregulation of testicular follicle-stimulating hormone receptors in mice. J. Exp. Zool. 278, 234-242, 1997.
  • Takase, M., Tsutsui, K. and Kawashima, S. Prolactin augments luteinizing hormone binding to rat Leydig cells in serum-free culture. J. Biosci. 21, 511-517, 1996.
  • Nakamura, M., Yamanobe, T. and Takase, M. Localization and purification of serum albumin in the testis of Xenopus laevis. Zool. Sci. 11, 285-290, 1994.
  • Takase, M., Tsutsui, K. and Kawashima, S. Effects of prolactin and bromocriptine on the regulation of testicular luteinizing hormone receptors in mice. J. Exp. Zool. 256, 200-209, 1990.
  • Takase, M., Tsutsui, K. and Kawashima, S. Effects of PRL and FSH on LH binding and number of Leydig cells in hypophysectomized mice. Endocr. J. 37, 193-203, 1990.
  • Takase, M., Tsutsui, K. and Kawashima, S. Changes in testicular gonadotropin receptors and plasma gonadotropin and testosterone concentrations after sexual maturation in mice. J. Sci. Hiroshima Univ., Ser. B, Div. 1. 33, 113-125, 1989.
  • Takase, M., Tsutsui, K. and Kawashima, S. Inhibitory effect of Sertoli cell- cultured media on LH binding to mouse Leydig cells in culture. Endocr. J. 35, 285-293, 1988.
  • Iguchi, T., Takei, T., Takase, M. and Takasugi, N. Estrogen perticipation in induction of cervicovaginal adenosis-like lesions in immature mice exposed prenatally to diethylstilbestrol. Acta Anat. 127, 110-114, 1986.
  • Iguchi, T., Takase, M. and Takasugi, N. Development of vaginal adenosis-like lesions and uterine epithelial stratification in mice exposed perinatally to diethylstilbestrol. Proc. Soc. Exp. Biol. Med. 181, 59-65, 1986.
  • Iguchi, T., Takase, M. and Takasugi, N. Persistent anovulation in the ovary of mice treated with human chorionic gonadotropin starting at different early postnatal ages. IRCS Med. Sci. 14, 187-188, 1986.
  • Takasugi, N., Iguchi, T., Kurihara, J., Tei, A. and Takase, M. Changes in gonads of male and female offspring of mice receiving a continuous intravenous infusion of human chorionic gonadotropin during gestation. Exp. Clin. Endocrinol. 86, 273-283, 1985.

[変態]

  • Y. Nakai, K. Nakajima and Y. Yaoita. An inhibitor of thyroid hormone synthesis protects tail skin grafts transplanted to syngenic adult frogs. Zoological Science2017 Oct;34(5):414-418.
  • T. Nakayama, K. Nakajima, A. Cox, M. Fisher, M. Howell, M. B. Fish, Y. Yaoita, R. M. Grainger. no privacy, a Xenopus tropicalis mutant, is a model of human Hermansky-Pudlak Syndrome and allows visualization of internal organogenesis during tadpole developmen. Developmental Biology 2017; 426: 472-486
  • K. Nakajima, T. Nakajima and Y. Yaoita. Generation of albino Cynops pyrrhogaster by genomic editing of the tyrosinase gene. Zoological Science 2016 June: 33(3): 290-294
  • Y. Nakai, K. Nakajima and Y. Yaoita. Ouro proteins are not essential to tail regression during Xenopus tropicalis metamorphosis. Genes to Cells 2016 March; 21(3): 275-286
  • T. Nakayama, M. Fisher, K. Nakajima, A. O. Odeleye, K. B. Zimmerman, M. B. Fish, Y. Yaoita, J. L. Chojnowski, J. D. Lauderdale, P. A. Netland and R. M. Grainger. Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients. Developmental Biology 2015 December; 408(2): 328-244
  • K. Nakajima and Y. Yaoita. Development of a new approach for targeted gene editing in primordial germ cells using TALENs in Xenopus. Biology Open 2015 March; 4(3): 259-266
  • Nakajima K, Yaoita Y. Highly efficient gene knockout by injection of TALEN mRNAs into oocytes and host transfer in Xenopus laevis. Biology Open 2015 February; 4(2): 180-185
  • Nakajima K, Yaoita Y. Comparison of TALEN scaffolds in Xenopus tropicalis. Biology Open 2013 November; 2: 1364-1370
  • Nakajima K, Nakai Y, Okada M, Yaoita Y. Targeted gene disruption in the Xenopus tropicalis genome using designed TALE nucleases. Zoological Science 2013 June; 30(6): 455-460 (This article is ranked as the Most Read Articles (2013 June) of Zoological Science.)
  • Okada M, Tazawa I, Nakajima K, Yaoita Y. Expression of the amelogenin Gene in the Skin of Xenopus tropicalis. Zoological Science 2013 Mar; 30(3): 154-159
  • Oka, T., Mitsui-Watanabe, N., Tatarazako, N., Onishi, Y., Katsu, Y., Miyagawa, S., Ogino, Y., Yatsu, R., Kohno, S., Takase M., Kawashima, Y., Ohta, Y., Aoki, Y., Guillette, L.T. Jr. and Iguchi, T. Establishment of transactivation assay systems using fish, amphibian, reptilian and human thyroid hormone receptors. J. Appl. Toxicol. 33: 991-1000, 2013.
  • Nakajima K, Nakajima T, Takase M, Yaoita Y. Generation of albino Xenopus tropicalis using zinc-finger nucleases. Development Growth & Differentiation 2012 Decomber; 54(9): 777-784.
  • Nakajima K, Fujimoto K, Yaoita Y. Regulation of thyroid hormone sensitivity by differential expression of the thyroid hormone receptor during Xenopus metamorphosis. Genes to Cells 2012 August; 17(8): 645-659.
  • Okada M, Nakajima K, Yaoita Y. Translational regulation by the 5’-UTR of thyroid hormone receptor α mRNA. Journal of Biochemistry. 2012 May; 151(5): 519-531.
  • Kashiwagi K, Kashiwagi A, Kurabayashi A, Hanada H, Nakajima K, Okada M, Takase M, Yaoita Y. Xenopus tropicalis: An Ideal Experimental Animal in Amphibia. Experimental Animals. 2010 July; 59(4): 395-405.
  • Hasebe T, Kajita M, Fujimoto K, Yaoita Y, Ishizuya-Oka A. Expression profiles of the duplicated matrix metalloproteinase-9 genes suggest their different roles in apoptosis of larval intestinal epithelial cells during Xenopus laevis metamorphosis. Dev Dyn. 2007 Aug; 236(8): 2338-2345.
  • Fujimoto K, Nakajima K, Yaoita Y. Expression of matrix metalloproteinase genes in regressing or remodeling organs during amphibian metamorphosis. Dev Growth Differ. 49(2): 131-143. 2007.
  • Tazawa I, Okumoto H, Kashiwagi A. Skin pigmentary variants in Rana nigromaculata. Journal of Clinical Biochemistry and Nutrition, vol. 38 (3): pp. 195-203 (April 19, 2006)
  • Tazawa I, Shimizu-Nishikawa K, Yoshizato K. A novel Xenopus laevis larval keratin gene, xlk2: Its gene structure and expression during regeneration and metamorphosis of limb and tail. Biochim Biophys Acta – Gene Structure and Expression, vol. 1759 (5): pp. 216-224 (May 24, 2006)
  • Furuno N, Tazawa I, Kashiwagi K, Kawakami S, Shinkai T, Yamashita M, Kashiwagi A
    The effect of hypergravity on bipolar spindle formation of meiosis II in Xenopus oocytes. Biological Sciences in Space, vol. 20 (3): 92-94 (2006)
    Fujimoto K, Nakajima K, Yaoita Y. One of the duplicated matrix metalloproteinase-9 genes is expressed in regressing tail during anuran metamorphosis. Dev Growth Differ. 48(4): 223-41. 2006.
  • Shiokawa K, Takayama E, Higo T, Kuroyanagi S, Kaito C, Hara H, Kajitani M, Sekimizu K, Tadakuma T, Miura K, Igarashi K, Yaoita Y. Occurrence of pre-MBT synthesis of caspase-8 mRNA and activation of caspase-8 prior to execution of SAMDC (S-adenosylmethionine decarboxylase)-induced, but not p53-induced, apoptosis in Xenopus late blastulae. Biochem Biophys Res Commun. 336(2): 682-91. 2005
  • Tazawa I, Kashiwagi A, Kashiwagi K, Furuno N. Effects of hypergravity on oocyte maturation in Xenopus laevis. Biological Sciences in Space, vol. 19 (4): pp. 242-244 (2005)
  • Sakamaki K, Takagi C, Kominami K, Sakata S, Yaoita Y, Kubota HY, Nozaki M, Yonehara S, Ueno N. The adaptor molecule FADD from Xenopus laevis demonstrates evolutionary conservation of its pro-apoptotic activity. Genes Cells. 9(12):1249-64. 2004.
  • Takayama E, Higo T, Kai M, Fukasawa M, Nakajima K, Hara H, Tadakuma T, Igarashi K, Yaoita Y, Shiokawa K. Involvement of caspase-9 in execution of the maternal program of apoptosis in Xenopus late blastulae overexpressed with S-adenosylmethionine decarboxylase. Biochem Biophys Res Commun. 325(4):1367-75. 2004.
  • Nakajima K, Yaoita Y. Dual mechanisms governing muscle cell death in tadpole tail during amphibian metamorphosis. Developmental Dynamics, 227: 246-255, 2003.
  • Yaoita Y. Inhibition of the nuclear transport of caspase-7 by its prodomain. Biochem. Biophys. Res. Commun. 291, 79-84, 2002.
    Shiokawa K, Kai M, Higo T, Kaito C, Yokoska J, Yasuhiko Y, Kajita E, Nagano M, Yamada Y, Shibata M, Muto T, Shinga J, Hara H, Takayama E, Fukamachi H, Yaoita
  • Y, Igarashi K. Maternal program of apoptosis activated shortly after midblastula transition by overexpression of S-adenosylmethionine decarboxylase in Xenopus early embryos. Comp. Biochem. Physiol. B. Biochem. Mol. Biol. 126, 149-155, 2000.
  • Nakajima K, Takahashi A, Yaoita Y. Structure, expression and function of the Xenopus laevis caspase family. J. Biol. Chem. 275, 10484-10491, 2000.
  • Shimizu-Nishikawa K, Tazawa I, Uchiyama K, Yoshizato K. Expression of helix-loop-helix type negative regulators of differentiation during regeneration in urodeles and anurans. Development, Growth and Differentiation, vol. 41 (6): pp. 731-743 (December, 1999)
  • Nakajima K, Yaoita Y. Construction of multiple-epitope tag sequence by PCR for sensitive Western blot analysis. Nucl. Acids Res. 25, 2231-2232, 1997.
  • Yaoita Y, Nakajima K. Induction of apoptosis and CPP32 expression by thyroid hormone in a myoblastic cell line derived from tadpole tail. J. Biol. Chem. 272, 5122-5127, 1997.
  • Yaoita Y, Shi YB, Brown DD. Xenopus laevis alpha and beta thyroid hormone receptors. Proc Natl Acad Sci U S A. 87(18), 7090-7094, 1990.
  • Yaoita Y, Brown DD. A correlation of thyroid hormone receptor gene expression with amphibian metamorphosis. Genes Dev. 4(11):1917-1924, 1990.

総説

  • Nakajima K, Fujimoto K, Yaoita Y. Programmed cell death during amphibian metamorphosis. Seminars in Cell & Developmental Biology. 16(2):271-280, 2005.
  • 中島圭介、矢尾板芳郎「両生類変態の分子機構」蛋白質 核酸 酵素、Vol. 50, No. 6, 717-723, 2005.
  • 矢尾板芳郎、中島圭介「両生類の変態とアポトーシス」医学のあゆみ、第187巻、第5号、452ー457、1998年。
  • 中島圭介、矢尾板芳郎「変態とアポトーシス」「Bio Science 用語ライブラリー アポトーシス」(三浦正幸、山田武編)、130ー131、羊土社、1996年。

[その他の分野]
(鈴木厚関係)

  • Igawa, T., Watanabe, A., Suzuki, A., Kashiwagi, A., Kashiwagi, K., Noble, A., Guille, M., Simpson D. E., Horb, M., Fujii, T. and Sumida, M. “Inbreeding ratio and genetic relationships among strains of the western clawed frog, Xenopus tropicalis.” PLoS ONE 10(7): e0133963 (2015).

(高瀬稔関係)

  • Nakajima, K., Nakajima, T., Takase, M. and Yaoita, Y. Generation of albino Xenopus tropicalis using zinc-finger nucleases. Dev. Growth Differ. 54, 777-784, 2012.
  • Takase, M., Haraguchi, S., Hasunuma, I., Kikuyama, S., Tsutsui, K. Expression of cytochrome P450 side-chain cleavage enzyme mRNA and production of pregnenolone in the brain of the red-bellied newt Cynops pyrrhogaster. Gen. Comp. Endocrinol. 170, 468-474, 2011.
  • Kashiwagi, K., Kashiwagi, A., Kurabayashi, A., Hanada, H., Nakajima, K., Okada, M., Takase, M., Yaoita, Y. Xenopus tropicalis: an ideal experimental animal in amphibian. Exp. Anim. 59, 395-405, 2010.
  • Pickford, D.B., Larroze, S., Takase, M., Mitsui, N., Tooi, O., Santo, N. Investigating the potential for impacts of environmental endocrine disrupters on wild populations of amphibians in UK and Japan: status of historical databases and review of methods. Environ. Sci. 14, 297-317, 2007.
  • Takase, M., Ukena, K. and Tsutsui, K. Expression and localization of cytochrome P45011ß,aldo mRNA in the frog brain. Brain Res. 950, 288-296, 2002.
  • Tsutsui, K., Ukena, K., Usui, M., Sakamoto, H., Takase, M. Novel brain function: biosynthesis and actions of neurosteroids in neurons. Neurosci. Res. 36, 261-273, 2000.
  • Takase, M., Ukena, K., Yamazaki, T., Kominami, S. and Tsutsui, K. Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes. Endocrinology 140, 1936-1944, 1999.
  • Tsutsui, K., Ukena, K., Takase, M., Kohchi, C., Lea, R. W. Neurosteroid biosynthesis in vertebrate brains. Comp. Biochem. Physiol. C Pharmacol. Toxicol. Endocrinol. 124, 121-129, 1999.
  • Kashiwagi, A., Kashiwagi, K., Takase, M., Hanada, H., Yamashita, M., Naitoh, T. and Nakamura, M. Inhibitor and temperature effect on catalase in the liver of adult diploid and haploid Rana rugosa. Comp. Biochem. Physiol. 119, 235-239, 1997.
  • Kashiwagi, A., Kashiwagi, K., Takase, M., Hanada, H. and Nakamura, M. Comparison of catalase in diploid and haploid Rana rugosa using heat and chemical inactivation techniques. Comp. Biochem. Physiol. 118, 499-503, 1997.
  • Takase, M., Miura, I., Nakata, A., Takeuchi, T. and Nishioka, M. Cloning and sequencing of the cDNA encoding tyrosinase of the Japanese frog, Rana nigromaculata. Gene 121, 359-363, 1992.
  • Takasugi, N., Iguchi, T., Takase, M. and Takei, T. Regression of mammary and adrenocortical tumors transplanted into iodotyrosine-pretreated mice. Proc. Japan Acad.,Ser. B. 62, 252-256, 1986.

(花田秀樹関係)

  • Hanada, H. (2015) Disruption of Vitamin E and Butylated Hydroxytoluene Antioxidant Function in Response to Paraquat-Induced Chromosomal Damage in Cultured Anuran Leukocytes. Biology and Medicine 7, 222. doi:10.4172/0974-8369.1000222.
  • Hanada H, Kobuchi H, Yamamoto M, Kashiwagi K, Katsu K, Utsumi T, Kashiwagi A, Sasaki J, Inoue M, Utsumi K. (2013) Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening. Hereditas 150, 1-9.
  • Hanada, H. (2012) Phenolic antioxidant 2,6-di-tert-butyl-p-cresol (vitamin E synthetic analogue) does not inhibit 1,1’-dimetyl-4,4’-bipyridium dichloride (paraquat)-induced structural chromosomal damage in cultured leukocytes of the dark-spotted-frog Pelophylax (Rana) nigromaculatus. Hereditas 149, 173-177.
  • Yanagisawa, M., Furuno, N.*, Watanabe, M., Kashiwagi, K., Hanada, H., Shinkai, T., Yoshitome, S., Kubo, H., Sakai, M., Fujii, H., Suzuki, K., Yamashita, M. and
  • Kashiwagi, A. (2012) Hypergravity specifically effects head formation in the Xenopus embryos raseid under hypergravity condition. Space Utili. Res. 28, 172-175.
  • Fujiwara, Y., Kashiwagi, K., Nakagawa, M., Shinkai, T., Yanagisawa, M., Furuno, N., Hanada, H., Suzuki, K., Katsu, K., Yamashita, M., Yamamoto, T., Tanimoto, Y. and Kashiwagi, A. (2012) Effects of magnetically controllled microgravity and hypergravity environment on amphibian behavior. Space Utili. Res. 28, 176-179.
  • Yanagisawa, M., Kashiwagi, K., Hanada, H., Shinkai, T., Yoshitome, S., Kubo, H., Sakai, M., Fujii, H., Yamashi, M., Kashiwagi, A. Furuno, N. , Watanabe, M. (2012) Analysys of the head-defects caused by hypergravity in early Xenopus embyos. Biol. Sci. Space 26, 1-6.
  • Hanada, H. (2011) Dl-α-tocopherol enhances the herbicide 1,1′-dimetyl-4,4′-bipyridium dichloride (paraquat, PQ) genotoxicity in cultured anuran leukocytes. Hereditas 148, 118-124.
  • Kashiwagi, K., Kashiwagi, A., Kurabayashi, A., Hanada, H., Nakajima, K., Okada, M., Takase, M., Yaoita, Y. (2010) Xenopus tropicalis: An ideal experimental animal in Amphibia. Exp. Anim. 59(4), 395-405.
  • Kashiwagi, K., Furuno, N., Hanada, H., Kitamura, S., Utsumi, K., Taniguchi,K., Ohta, S., Sugihara, K., Suzuki, K., Kashiwagi, A. (2009) Review. Disruption of thyroid hormone function by environmental pollutants. J. Health Sci. 55, 147-160.
  • 渡部稔・柳澤誠・古野伸明・柏木啓子・新海正・花田秀樹・吉留賢・久保英夫・坂井雅夫・藤井博匡・山下雅道・柏木昭彦. (2009)過重力下で見られるアフリカツメガエル頭部形成異常の解析.  Space Utiliz Res. 25, 155-158.
  • 新海 正・柏木昭彦・柏木啓子・古野伸明・花田秀樹・久保英夫・吉留 賢・渡部 稔・藤井博匡・坂井雅夫・山下雅道. (2008) 過重力によるニシツメガエル脳下垂体―甲状腺系の機能低下に対する甲状腺ホルモン投与の効果. Space Utiliz. Res. 24, 24-26.
  • Kashiwagi, K., Hanada, H., Yamamoto, T., Goto, Y., Furuno, N., Kitamura, S., Ohta, S., Sugihara, K., Taniguchi, K. Tooi, O., Suzuki, K., Yoshizato, K., Kashiwagi, A. (2008) 2-Hydroxy-4-methoxybenzophenone (HMB) and 2,4,4’-trihydroxybenzophenone (THB) suppress amphibian metamorphosis. Progress in Safety Science and Technology, VII, Part A, 970-976.
  • Mitsui, N., Fujii, T., Miyahara, M., Oka, T., Kashiwagi, A., Kashiwagi, K., Hanada, H., Urushitani, H., Santo, N., Tooi, O. and Iguchi, T. (2005) Development of metamorphosis assay using Silurana tropicalis for the detection of thyroid system-disrupting chemicals. Ecotoxicology and Environmental Safety 64, 281-287.
  • 柏木昭彦, 古野伸明, 柏木啓子, 花田秀樹, 川上智美, 渡部 稔, 山下雅道(2005)両生類の生活環に対する重力影響-初期発生、形態形成や変態の形態学的および分子生物学的解析. Space Utilization Research, 21, 270-273.
  • Kitamura, S., Kato, T., Iida, M., Jinno, N., Suzuki, T., Ohta, S., Fujimoto, N., Hanada, H., Kashiwagi, A. (2005) Anti-thyroid hormonal activity of tetrabrmobisphenol A, a flame retardant, and related compounds: affinity to the mammalian thyroid hormone receptor, and effect on tadpole metamorphosis. Life Science, 76, 1589-15601.
  • 柏木昭彦, 川上智美, 花田秀樹, 柏木啓子, 山下雅道. (2004) 無尾両生類の変態におけるアポトーシスや体の形態・機能の変化と重力. Space Utilization Research, 20, 57-60.
  • 柏木昭彦、柏木啓子、花田秀樹、久保英夫、新海 正、藤井博匡, 山下雅道. (2003)    無尾両生類の変態におけるアポトーシスや体の形態・機能の変化と重力. Space Utilization Research, 19, 45-48.
  • Hanada, H., Katsu, K., Kanno, T., Sato, E. F., Kashiwagi, A., Sasaki, J., Inoue, M., Utsumi, K. (2003) Cyclosporin A inhibits thyroid hormone-induced shortening of the tadpole tail through membrane permeability transition. Comparative Biochemistry and physiology, B135, 473-483.
  • Kashiwagi, A., Hanada, H., Kawakami, S., Kubo, H., Shinkai, T., Fujii, H., Kashiwagi, K. (2003) Effects of high gravity on amphibian development. Biological Sciences in Space, 17, 215-216.
  • 柏木昭彦, 柏木啓子, 花田秀樹, 久保英夫, 新海 正, 藤井博匡, 山下雅道 (2002) 無尾両生類の変態におけるアポトーシスや体の形態・機能の変化と重力. Space Utilization Research, 18, 109-112.
  • Hanada, H. (2002) G and C banding show structural differences between the Z and W chromosomes in the frog Buergeria buergeri. Hereditas, 136, 151-154.
  • 柏木昭彦、花田秀樹、内海耕慥 (2000) 無尾両生類の変態におけるアポトーシスや体の形態・機能の変化と重力。Space Utilization Research 16, 63-66.
    Ohtani, H, Miura, I, Hanada, H, Ichikawa, Y. (2000) Alteration of the sex determining system resulting from structural change of the sex chromosomes in the frog Rana rugosa. Journal of Experimental Zoology 286, 313-319.
  • Kashiwagi, A., Hanada, H., Yabuki, M., Utsumi, K. (2000) Reactive oxygen species and the mechanism for tail apoptosis in Rana rugosa and Rana japonica. Recent Development in Comparative Biochemistry and Physiology 1, 51-66.
  • Kashiwagi, A., Hanada, H., Yabuki, M., Kanno, T., Ishisaka, R., Sasaki, M., Inoue, M., Utsumi, K. (1999), Thyroxine enhancement and the role of reactive oxygen species in tadpole tail apoptosis. Free Radical Biology and Medicine 26, 1001-1009.
  • Ryuzaki, M., Hanada, H., Okumoto, H., Takizawa, N., Nishioka, M. (1999) Evidence for heteromorphic sex chromosomes in males of Rana tagoi and Rana sakuraii in Nishitama district of Tokyo (Anura: Ranidae). Chromosome Research 7, 31-42.
  • Kashiwagi, A., Kashiwagi, K., Takase, M., Hanada, H., Yamashita, M., Naitoh, T., Nakamura, M. (1998) Inhibitor and temperature effect on catalase in the liver of adult diploid and haploid Rana rugosa. Comparative Biochemistry and Physiology, B119, 235-239.
  • Hanada, H., Kashiwagi, A., Takehara, Y., Kanno, T., Yabuki, M., Sasaki, J., Inoue, M., Utsumi, K. (1997) Do reactive oxygen species underlie the mechanism of apoptosis in the tadpole tail? Free Radical Biology and Medicine 23, 294-301.
  • Kashiwagi, A., Kashiwagi, K., Takase, M., Hanada, H., Nakamura, M. (1997) Comparison of catalase in diploid and haploid Rana rugosa using heat and chemical inactivation techniques. Comparative Biochemistry and Physiology, B118, 199-503.
  • Miura, I., Ohtani, H., Hanada, H., Ichikawa, Y., Kashiwagi A., Nakamura, M. (1997) Evidence for two successive pericentric inversions in sex lampbrush chromosomes of Rana rugosa (anura: Ranidae). Chromosoma 106, 178-182.
  • Miura, I., Ohtani, H., Hanada, H., Ichikawa, Y., Kashiwagi A., Nakamura, M. (1997) Evidence for two successive pericentric inversions in sex lampbrush chromosomes of Rana rugosa (anura: Ranidae). Chromosoma 106, 178-182.
  • Yamamoto, S., Kondo, Y., Hanada, H., Nakamura, M. (1996) Strong expression of the calreticulin gene in the liver of Rana rugosa tadopoles, but not adult frogs. Journal of Experimental Zoology, 275, 431-443.
  • Nishioka, M., Hanada, H. (1994) Sex of reciprocal hybrids between the Hamakita (XX-XY type) population and the Murakami (ZW- ZZtype) population in Rana rugosa.. Scientific Report of the Laboratory for Amphibian Biology, Hiroshima University, 13, 35-50.
  • Nishioka, M., Hanada, H., Miura, I., Ryuzaki, M. (1994) Four kinds of sex chromosomes in Rana rugosa. Scientific Report of the Laboratory for Amphibian Biology, Hiroshima University, 13, 1-34.

総説

  • Hanada, H., Kashiwagi, K., Suzuki, K., Tazawa, I., Yamamoto, T., Kashiwagi, A. (2014) Minireview: Suppression of anuran metamorphosis by synthetic chemical compounds: In Lambert, H. (Ed): Frogs Genetic Diversity, Neural Development and Ecological Implications. NOVA Science Publishers, New York, pp.73-88.
  • Hanada, H. (2013) Herbicide paraquat genotoxicity-enhancement by the phenolic antioxidants dl-α-tocopherol and 2,6-di-tert-butyl-p-cresol. In: Handbook on Herbicides: Biological Activity, Classification and Health & Environmental Implications. Editors: Daiki Kobayashi and Eito Watanabe, NOVA Science Publishers, New York, pp.191-211.
  • Kashiwagi, K., Furuno, N., Kitamura, S., Ohta, S., Sugihara, K., Utsumi, K., Hanada, H., Taniguchi, K., Suzuki, K. and Kashiwagi, A. (2009) Review. Disruption of thyroid hormone function by environmental pollutants. J. Health Sci. 55, 147-160.
  • Kashiwagi, A., Utsumi, K., Kashiwagi, K., Ohta, S., Sugihara, K., Hanada, H., Kitamura, S. (2008) Effects of endocrine disrupting chemicals on amphibian metamorphosis and mitochondrial membrane permeability transition. J. Health Sci. 54, 273-280.
  • 著書
    柏木 昭彦、花田 秀樹、矢吹 宗久、菅野 智子、石坂 瑠美、竹原 良記、佐々木順造、井上 正康、内海 耕慥( 1998), 生命誕生と生物の生存戦略。日本アクセル・シュプリンガー出版, メディカルトリビューンブックス.
  • Proceeding reports:
  • Kashiwagi, A., Sanoh, S., Kashiwagi, K., Hanada, H., Suzuki, K.T., Shinkai, T., Yamamoto, T., Ohta, S. 2016. Suppression in amiodarone on Xenopus metamorphosis. International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research.(査読あり)
  • Sanoh, S., Mori, Z., Suzuki, K.T., Kashiwagi, K., Hanada, H., Shigeta, M., Yamamoto, T., Sugihara, K., Kitamura, S., Kashiwagi, A., Ohta, S., 2016. Developmental changes of drug-metabolizing enzymes related to accumulation of chemicals in tadpoles and adult frogs. International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research. (査読あり)
  • Sasado, T., Kashiwagi, K., Hanada, H., Seki, S., Suzuki, K., Yamamoto, T., Kashiwagi, A., Naruse, K. 2016. A simple sperm-cryopreservation method established for medaka (Oryzias latipes) works in Xenopus laevis, X. tropicalis, and several other frogs. International Meeting on Aquatic Model Organisms for Human Disease and Toxicology Research. (査読あり)
  • Kashiwagi, A., H. Hanada, M. Yabuki, T. Kanno, R. Ishisaka, J. Sasaki, Inoue, M., Utsumi, K. (1998) An investigation into the role of reactive oxygen species in tadpole tail apoptosis by means of thyroxine enhancement. IBC’s Fifth Annual Conference on Apoptosis, International Business Communications, 281. (査読あり)

その他の研究報告等

  • 花田秀樹.(2005), オタマジャクシの尾部アポトーシスにおけるカルニチンの役割. 平成15-16年度科学研究費補助金(基盤研究(c)(2))研究成果報告書.
  • 柏木昭彦, 柏木啓子, 花田秀樹, 久保英夫, 新海正, 藤井博匡, 山下雅道. (2002), 無尾両生類の変態における変態におけるアポトーシスや体の形態・機能の変化と重力. 平成13年度 宇宙基地利用基礎実験費研究成果報告書, pp.22-41.
  • 柏木昭彦, 花田秀樹, 柏木啓子, 吉里勝利, 武石全慈, 倉本満, 小野勇一, 門上希和夫.(2002), カエル細胞に及ぼすトリニトロトルエンの細胞遺伝学的影響. 北九州市における外因性内分泌攪乱化学物質の野生生物に与える影響に関する検討委員会(平成13年度報告書). 北九州市 pp.別添3-7.
  • 柏木昭彦, 武石全慈, 倉本満, 柏木啓子, 花田秀樹, 吉里勝利.(2001), 北九州山田緑地ヤマアカガエルに見られる四肢異常の遺伝について. 北九州市における外因性内分泌攪乱化学物質の野生生物に与える影響に関する検討委員会(中間とりまとめ). 北九州市 pp.60-75.