We are studying molecular mechanisms of chordate evolution and adaptation through comparative functional analysis of developmental genes in the "living fossil" amphioxus and a variety of frog spieces. We are also studying genomic and epigenomic mechanisms involved in organ regeneration and genetic diseases by generating a variety of genetically modified pipid frogs using leading-edge technologies, such as high-throughput transgenesis and genome editing.
Associate Prof.: Takeshi Igawa Ph.D.
Profiles of Faculty and Research Scholars*
Technical Staff, Nanoka Suzuki
*Contact address, educational and research activities of the staffs are referable in Profiles of Faculty and Research Scholars.
Nusrat Hossain（D3）：Development of?Xenopus?as a high-throughput modeling system for human diseases caused by non-coding mutations
Bagus Priambodo（D1）：Identification of genomic diversity and selection in “hot-spring frog”, Buergeria japonica
Ou Yushi（M2）： Functional analysis of craniofacial disease genes using Xenopus as a model system
Yusuke Sakaguchi（M2）：Analysis of the evolution of cis-regulatory mechanisms that led to the evolution from monocular to binocular
Mana Yoshida（M2）：Mechanisms of activation of regenerative programs by inflammatory signals via epigenetic regulation
Kento Shiraga（M2）：Identification and functional analysis of genes related to high temperature tolerance in the Ryukyu bell-ring frog
Yuka Asaeda（Ｍ1）：Searching for genetic variation in environmental adaptation in the Ryukyu bell-ring frog.
Hinako Kato（Ｍ1）：Validation of the genetic mutations detected in patients with premature cranial suture fusion.
We are using dry and wet leading-edge technologies in our research, which include next-generation sequencing, comparative genomics, high-throughput transgenesis, genome editing, bio-imaging with fluorescent proteins, chromatin immunoprecipitation, etc. Feel free to contact us, if you are interested in leading-edge genome evolution studies, molecular ecology of wild amphibian species, or basis of human genetic diseases.