Research Group of Evolutionary Developmental Genomics

Introduction

We are studying molecular mechanisms of chordate evolution and adaptation through comparative functional analysis of developmental genes in the "living fossil" amphioxus and a variety of frog spieces. We are also studying genomic and epigenomic mechanisms involved in organ regeneration and genetic diseases by generating a variety of genetically modified pipid frogs using leading-edge technologies, such as high-throughput transgenesis and genome editing.

Molecular evolution of developmental genes driven by whole genome duplication
Epigenetic regulation of the genes related to evolution and development of eye
Evolutionary genomics of wild amphibian species
Developmental process of neural tube in Xenopus

Topics

Snapshot

 

Staff

Professor: Hajime Ogino Ph.D.

リンク

Profiles of Faculty and Research Scholars*

Assistant Prof.: Takeshi Igawa Ph.D.

リンク

Profiles of Faculty and Research Scholars*

Personal website

Assistant Prof.: Makoto Suzuki Ph.D.

Link

Profiles of Faculty and Research Scholars*

researchmap

Technical Staff, Nanoka Suzuki

*Contact address, educational and research activities of the staffs are referable in Profiles of Faculty and Research Scholars.

Students

研究指導学生:研究課題
Nusrat Hossain(D3):Development of?Xenopus?as a high-throughput modeling system for human diseases caused by non-coding mutations
Bagus Priambodo(D1):Identification of genomic diversity and selection in “hot-spring frog”, Buergeria japonica
Ou Yushi(M2): Functional analysis of craniofacial disease genes using Xenopus as a model system
Yusuke Sakaguchi(M2):Analysis of the evolution of cis-regulatory mechanisms that led to the evolution from monocular to binocular
Mana Yoshida(M2):Mechanisms of activation of regenerative programs by inflammatory signals via epigenetic regulation
Kento Shiraga(M2):Identification and functional analysis of genes related to high temperature tolerance in the Ryukyu bell-ring frog
Yuka Asaeda(M1):Searching for genetic variation in environmental adaptation in the Ryukyu bell-ring frog.
Hinako Kato(M1):Validation of the genetic mutations detected in patients with premature cranial suture fusion.
Hinayo Ogino(B4):
Narue Kunishige(B4):

Message

We are using dry and wet leading-edge technologies in our research, which include next-generation sequencing, comparative genomics, high-throughput transgenesis, genome editing, bio-imaging with fluorescent proteins, chromatin immunoprecipitation, etc. Feel free to contact us, if you are interested in leading-edge genome evolution studies, molecular ecology of wild amphibian species, or basis of human genetic diseases.