Research Unit of Regulatory Signals for Development/Regeneration

Introduction

We are studying the molecular mechanisms for mesodermal and neural development in the body axis formation of vertebrates and for the regulation of stem cells and tissue regeneration. Our goal is to clarify “how a single fertilized egg gives rise to a well-organized body during development” and “how amphibians are capable of regenerating organs and tissues after injury”. The African clawed frog Xenopus laevis and X. tropicalis are ideal model system for studying vertebrate embryogenesis/regeneration and the etiology of human genetic diseases, as frog eggs are accessible to a variety of genetic modification methods and embryological manipulations. We are particularly interested in the roles of cell signaling mediated by growth factors and downstream transcription factors. Recently, we discovered the essential roles of Zbtb14 in the formation of dorsal-ventral and anterior-posterior axes (Takebayashi-Suzuki et al., 2018), the regulation of neural development by the autism-related Clk2 (Virgirinia et al., 2019), and the importance of JunB in the initiation of cell proliferation during regeneration (Nakamura et al., 2020).

 

Staff

 

Associate Professor
Atsushi Suzui, Ph.D.

Links

Profiles Faculty and Research Scholars

 

Research Associate

Kimiko Takebayashi, M.D.

Links

researchmap

Students

Graduate Student

Regina Putri Virgirinia
Makoto Nakamura
Eri Takahashi
Yuka Moriyama

Undegraduater Student

Itsuki Kawakita
Takaaki Fukumoto

Message

In our laboratory, we have students from not only Hiroshima University but also other universities. We all enjoy science and education to contribute to the societies and aim at discovering novel molecular mechanisms regulating embryogenesis and regeneration. Throughout the year, we participate in a variety of research and educational activities including a joint project with high-school teachers. Please join us and enjoy together!